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Scientists in Germany have recently developed a nasal vaccine that shows promise in shutting down a Covid-19 infection at its early stages in the nose and throat. These experiments, conducted in hamsters, revealed that this live but weakened vaccine can prevent the virus from replicating in the upper airways, offering “sterilizing immunity” and stopping the illness from taking hold.
While this nasal vaccine has more hurdles to overcome before reaching the market, other similar vaccines in clinical trials or already in use are showing potential. China and India have rolled out nasal vaccines since last fall, although the effectiveness data is yet to be published.
In the US, despite progress in controlling Covid-19, the infection still persists, posing a threat to vulnerable groups. Researchers are looking at next-generation vaccines that aim to prevent the virus from causing illness, ultimately curbing the spread of infection.
Boosting mucosal immunity – the body’s defenses in the upper airways – can be key in achieving this goal. The new nasal vaccine presents the whole coronavirus to the body, unlike current vaccines targeting only spike proteins, enhancing the immune arsenal against a broader range of targets.
Despite the promising results, experts advise caution until further tests are conducted, including trials in primates and humans. The research team is partnering with RocketVax, a Swiss company, to proceed with phase I clinical trials for this easy and simple MCA solution.
As efforts continue to develop vaccines that induce mucosal immunity and withstand virus mutations, scientists are vigilant as more contagious variants emerge. The live weakened nasal vaccine, although needing updates for newer strains like Omicron, exhibits potential in neutralizing the virus effectively.
In a competitive landscape of Covid-19 vaccine development, companies like Codagenix are advancing with live attenuated virus vaccines, following a similar approach as the German team. While there are challenges in creating effective nasal vaccines, particularly for respiratory infections, the live attenuated virus approach holds promise, akin to successful vaccines for measles and rubella.
Ultimately, implementing live vaccines safely is crucial, making them unsuitable for individuals with compromised immunity. With diligent testing and monitoring, live weakened virus vaccines like the nasal Covid-19 vaccine may offer a powerful tool in combating the virus effectively.